Genetic Predisposition to Ischemic Stroke
نویسندگان
چکیده
منابع مشابه
Genetic Predisposition to Ischemic Stroke
BACKGROUND AND PURPOSE The prediction of genetic predispositions to ischemic stroke (IS) may allow the identification of individuals at elevated risk and thereby prevent IS in clinical practice. Previously developed weighted multilocus genetic risk scores showed limited predictive ability for IS. Here, we investigated the predictive ability of a newer method, polygenic risk score (polyGRS), bas...
متن کاملDifferences in Common Genetic Predisposition to Ischemic Stroke by Age and Sex
BACKGROUND AND PURPOSE Evidence from epidemiological studies points to differences in factors predisposing to stroke by age and sex. Whether these arise because of different genetic influences remained untested. Here, we use data from 4 genome-wide association data sets to study the relationship between genetic influence on stroke with both age and sex. METHODS Using genomic-relatedness-matri...
متن کاملGenetic predisposition to stroke in relatives of hypertensives.
BACKGROUND AND PURPOSE The genetic basis of stroke is poorly understood. We evaluated patterns of familial aggregation of hypertension and stroke to test the hypothesis that inherited susceptibility to these disorders may be determined by a common set of factors. METHODS Genealogical and medical history information was obtained for a cohort of 354 hypertensive probands ascertained in a clinic...
متن کاملGenetic predisposition to stroke in spontaneously hypertensive rats.
Hypertension and stroke in spontaneously hypertensive rats (SHR) were investigated genetically using stroke-prone SHR (A3), stroke-resistant SHR (C) and their hybrids, hybrid of A3 and C (F1), offspring of F1 X F1 (F2), and those of backcrossing of F1 to the respective parental strains, BC(F1 X A3) and BC(F1 X C). The average blood pressure measured without anesthesia increased in the following...
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ژورنال
عنوان ژورنال: Stroke
سال: 2017
ISSN: 0039-2499,1524-4628
DOI: 10.1161/strokeaha.116.014506